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世界华人消化杂志 2007年3月28日; 15(9): 964-969 ISSN 1009-3079 CN 14-1260/R
临床研究 CLINICAL RESEARCH
幽门螺杆菌与胃黏膜bFGF, FGFR-2表达的关系及意义
李 信, 姜海行, 陈 罡, 雷 琳, 覃山羽
胃癌是人类最常 见的恶性肿瘤, 其 发生机制目前尚 未明确. 1994年, 世界卫生组织属 下的国际癌肿研 究机构就宣布了 H pylori 是人类胃 癌的Ⅰ类致癌原, 但H pylori 致胃癌 发生的确切作用 机制至今尚未明 了. bFGF是一种 肽类细胞生长因 子, 属于成纤维细 胞生长因子家族, 通过与相关受体 的结合发挥促进 细胞增殖,毛细 血管形成,创伤 修复等作用.
■背景资料
李信, 姜海行, 雷琳, 覃山羽, 广西医科大学第一附属医院消 化内科 广西壮族自治区南宁市 530021 陈罡, 广西医科大学病理学教研室 广西壮族自治区南宁市 530021
李信, 硕士研究生, 主要从事幽门螺杆菌及胃癌发病机制的研 究. 通讯作者: 姜海行, 530021, 广西壮族自治区南宁市双拥路22 号, 广西医科大学第一附属医院消化内科. jihaxi@263.net 电话: 0771-5356501 传真: 0771-5354506 收稿日期: 2006-09-11 接受日期: 2007-01-04
status of H pylori infection. RESULTS: The expression of bFGF and FGFR-2 in CSG patients were significantly lower than those in the other patients (IM: χ2 = 4.002, P < 0.05; χ2 = 4.163, P < 0.05; Dys: χ2 = 15.779, P = 0.000; χ2 = 15.949, P = 0.000; GC: χ2 = 24.110, P = 0.000; χ2 = 18.736, P = 0.000). The expression of bFGF and FGFR-2 in IM patients were significantly lower than those in Dys and GC patients (Dys: χ2 = 4.258, P < 0.05; χ2 = 4.212, P < 0.05; GC: χ2 = 7.786, P < 0.01; χ2 = 4.687, P < 0.05). But there was no significant difference between Dys and GC patients. The positive rates of bFGF and FGFR-2 expression were significantly higher in H pylori-infected IM and Dys patients than those in the patients without H pylori infection (IM: χ2 = 10.076, P < 0.01; χ2 = 7.535, P < 0.01; Dys: χ2 = 11.501, P < 0.01; χ2 = 8.330, P < 0.01). The positive rates of bFGF and FGFR-2 expression in H pylori-infected Dys patients were significantly higher than those in GC group (bFGF: χ2 = 4.201, P < 0.05; FGFR-2: χ2 = 3.982, P < 0.05), while no significant difference was found between GC and IM patients. The expression of bFGF in Dys and IM patients without H pylori infection were significantly lower than that in GC patients (Dys: 2 2 χ = 5.736, P < 0.05; IM: χ = 17.113, P = 0.000), and FGFR-2 expression in H pylori-negative IM patients was significant lower than that in GC patients (χ2 = 11.091, P < 0.05). No significant difference was found between H pylori-negative Dys and GC patients. CONCLUSION: H pylori may induce over-expression of bFGF and FGFR-2 in gastric mucosal epithelia, which may play a vital role in the carcinogenesis of stomach cancer.

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