*
依折麦布:降低胆固醇及额外作用
LDL-C
在动脉粥样硬化形成中的作用
LDL是含载脂蛋白B的颗粒
Murphy HC et al. Biochemistry. 2000;39(32):9763–9770.
甘油三酯和胆固醇酯组成疏水核心
Apo B
表面覆以单层磷脂和游离胆固醇
CV risk increases with increased plasma apo B lipoproteins
Blood
Apo B lipoprotein
particles
Modification
Macrophage
Monocytes bind to
adhesion molecules
Tabas I et al. Circulation. 2007;116(16):1832–1844. Williams KJ, Tabas I. Arterioscler Thromb Vasc Biol. 1995;15:551–561.
Williams KJ, Tabas I. Arterioscler Thromb Vasc Biol. 2005;25:1536–1540. Hoshiga M et al. Circ Res. 1995;77(6):1129–1135.
Merrilees MJ, Beaumont B. J Vasc Res. 1993;30(5):293–302. Nakata A et al. Circulation.1996;94(11):2778–2786.
Steinberg D et al. N Engl J Med. 1989;320(14):915–924.
Smooth muscle
循环中Apo B 水平越低越不利于脂质沉积
Foam cell
Maladaptive
inflammatory response
大部分急性冠脉综合征的发病原因:
动脉板块破裂导致血栓形成
超越降LDL-C的疗效
聚焦降胆固醇的两个作用机制:合成与吸收
其他脂质参数
脂蛋白残粒
植物甾醇
Hs-CRP
脂病(Adiposopathy):流行病学
Figure 1. Distributions of body mass index (BMI) in SHIELD and NHANES
Bays HE, Chapman RH, Grandy S._ Int J Clin Pract, May 2007, 61, 5, 737–747
BMI 和 代谢性疾病的相关性
NHANES 1999-2002
18.5-24.9
25-26.9

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