Kawasaki Disease
Mucocutaneous lymph node syndrome
Ma Lian
Introduction
Kawasaki disease (KD) is a common vasculitic disorder usually seen in children below 5 years of age
The leading cause of acquired heart disease in children
Kawaski T.
Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children: clinical observations of 50 cases.
Jpn J Allergol.1967; 16 :178 –222

China kawasaki disease
Epidemiologic study of admitted children with Kawasaki disease in Beijing from 1995 to 1999 :The incidence of KD in Beijing is lower than that reported in Japan, similar to the incidence in the United States and higher than in those other Western countries.
Etiology
No one knows what causes Kawasaki disease.
But it is thought to start from an infection or from exposure to some toxin.
There is no firm evidence that the disease can spread from one person to another.
Superantigen-producing bacteria.
Histroy
Kawasaki disease has 3 stages, as follows
Acute stage (1-11 d)
Subacute stage (11-30 d)
Convalescent/chronic phase (>30 d)
Acute stage (1-11 d)
1. High fever (temperature >39℃)
2. Nonexudative bilateral conjunctivitis (90%)
3. Polymorphous erythematous rash
4. Acral erythema and edema that impede ambulation
5. Strawberry tongue and lip fissures
6. Lymphadenopathy (75%), generally a single, enlarged, nonsuppurative cervical node measuring approximately 1.5 cm

Acute stage
Nonexudative bilateral conjunctivitis (90%)
Acute stage
Polymorphous erythematous rash
Acute stage
Acral erythema and edema that impede ambulation
Acute stage
Strawberry tongue and lip fissures
Acute stage
Lymphadenopathy (75%), generally a single, enlarged, nonsuppurative cervical node measuring approximately 1.5 cm

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