WhatPhysicistscandoinBiology
PikYinLai 黎璧贤 Dept.ofPhysics&GraduateInstituteofBioPhysics CenterforComplexSystems, NationalCentralUniversity,ChungLi,Taiwan320
Email:pylai@phy.ncu.edu.tw
http://www.phy.ncu.edu.tw/~ibp/
Physicsisvitalinbreakthroughinlifesciences
Breakthroughinphysicalinstrument:opticalmicroscope(Hooke,1665), amplifier,Xray,electronmicroscope,MRI,SPM,massspectrometer, Singlemoleculemicroscopy,….
Nobellaureatesinphysiology/medicine thatwerephysicists/hadphysicstraining: GeorgvonBékésy(physicalmechanismofthecochlea,1961) FrancisCrick(DNA,1962) AlanHodgkin(nervecell,1963) HaldanHartline(visualprocessesintheeye,1967) MaxDelbrück(bacteriophage— ,1969) RosalynYalow(radioimmunoassaysofpeptidehormones,1977) WernerArber(restrictionenzymes,1978) ErwinNeher(singleionchannelsincells,1991) PaulGreengard(signaltransductioninnervoussystems,2000) LelandHartwell(regulatorsofcellcycle,2001) PeterMansfield(NMR,2003)…… Others:Schroedinger,Cooper,
WhatisBiophysics
BiophysicalSocietydefinesas:"thatbranchofknowledgethatappliesthe principlesofphysicsandchemistryandthemethodsofmathematical analysisandcomputermodelingtounderstandhowthemechanismsof biologicalsystemswork".
WhyBioPhysics
MaterialNatureofBiosubstancesaffect Biologicalproperties.(Evolutionmadeuse ofthephysicalpropertiesofbiomaterials) Physicalprinciples&Lawsholdsfrom microscopiclevelmacroscopiclevel TraditionalBiologyisdescriptive,non quantitative
WhyBioPhysics
Physicsisuniversal. Riseofmolecularbiology:DNA,RNA,protein, ATP…areuniversalinalllivingmatters UniversalityinCentralDogma: DNA RNA protein Biologicalfunctions… New,interesting,exciting&useful. Lotsofunsolvedimportantproblems. Techniques&Methodologyinphysicscanprobe thefundamentalprinciplesinbiosystemsofa widespectrumofscalesinaquantitativeway.
 LengthScales: nm mxmmcmXmkm
DNA,RNA,protein,intracellular,virus,bacteria,Intercellular,collectivemotion,insects,animals/plants,migration

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