wlchang@ndmctsghedutw

◎Honors and Awards
1. Outstanding teacher 1987, 2002, 2004 National Defense Medical Center, Taipei, Taiwan, Republic of China 2. Outstanding teacher 2004 Ministry of National Defense, Taiwan,
Republic of China
3. Outstanding military healthcare person award 2000 Ministry of National Defense, Taiwan, Republic of China
◎Selected Publications
1. Chang, W.L.*; Chiu, L.W.; Lin, H.C. Immunosupressive flavones and lignans from Bupleurum scorzonerifolium. Phytochemistry 64 (8), 1375 – 1379 (2003), SCI, 26/136 (Plant science), IF= 1.889. 2. Cheng, Y.L.; Chang, W.L.; Lee, S.C.; Liu, Y.G.; Lin, H.C.; Chen, C.J.; Yen, C.Y.; Harn, H.J.* Acetone extract of Bupleurum scorzonerifolium inhibits proliferation of A549 human lung cancer cells via inducing apoptosis and suppressing telomerase activity. Life Sci. 73, 2383-2394 (2003). SCI, 32/72 (Medicine), IF= 1.944. 3. Cheng, Y.L.; Chang, W.L.; Lee, S.C.; Liu, Y.G.; Lin, H.C.; Chen, C.J.; Yu, D.J.; Yen, C.Y.; Harn, H.J.* Acetone Extract of Angelica sinensis Inhibits Proliferation of Human Cancer Cells via Inducing Cell Cycle Arrest and Apoptosis. Life Sci, 75, 1579 -1594 (2004), SCI, 32/72 (Medicine), IF= 1.944. 4. Lee, S.S.*; Chang, W.L. Cytotoxic natural products from Formosan plants and marine organisms. Current of Medicinal Chemistry 11, 1461-1477 (2004). SCI, 4/37 (Medicinal Chemistry), IF= 4.409. 5. Ding, H.Y.; Chen, Y.Y.; Chang, W.L.*; Lin, H.C. Flavonoids from the Flowers of Pueraria lobata. J. Chin. Chem. Soc. 51, 1425 –1428 (2004). SCI,
55/110 (Chemistry), IF=0.635.
6. Ding, H.Y.; Chen, Y.P.; Chang, W.L.*; Lin, H.C. Isoflavonoids and but-2-enolides from the roots of Pueraria lobata. Chin. Pharm. J. 56, 31-35 (2004). 7. Cheng, Y.L.; Lee, S.C.; Lin, S.Z.; Chang, W.L.*; Chen, Y.L.; Tsai, N.M.; Liu, Y.G.; Tzao, C.; Yu, D.S.; Harn, H.J.* Anti-proliferative activity of Bupleurum scorzonerifolium in A549 human lung cancer cells in vitro and in vivo. Cancer Letters, 222, 183 - 193 (2005), SCI, 49/123, IF= 2.938. 8. Tsai, N.M.; Lin, S.Z.; Lee, C.C.; Chen, S.P.; Su, H.C.; Chang, W.L.; Harn, H.J. The Antitumor Effects of Angelica sinensis on Malignant Brain Tumors in Vitro and in Vivo. Clin Cancer Res. 11 (9), 3475 –3484 (2005), SCI, 11/120 (Oncology), IF= 6.511. 9. Chen, Y.L.; Lin, S.Z.; Chang, W.L.; Cheng, Y.L.; Harn, H.J.* Requirement for ERK activation in acetone extract identified from Bupleurum scorzonerifolium induced A549 tumor cell apoptosis and keratin 8

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